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Presence of SARS-CoV-2 RNA in the cornea of viremic patients with COVID-19

JAMA Ophthalmology Jan 27, 2021

Casagrande M, Fitzek A, Spitzer MS, et al. - In this case series carried out in a tertiary care facility, researchers sought to examine the presence of viral SARS-CoV-2 RNA in corneal discs of deceased patients with confirmed COVID-19 and evaluate viral genomic and subgenomic RNA load, possible infectivity, and histologic abnormalities. The sample consisted of 11 deceased COVID-19 patients (6 women [55%]; mean [SD] age, 68.5 [18.8] years) who were autopsied between March 20 and May 14, 2020. In the cornea of patients with COVID-19 viremia, viral genomic and subgenomic RNA of SARS-CoV-2 was observed. Even in donors with SARS-CoV-2 viremia, the risk of COVID-19 infection via corneal transplant is low, but more research is required to assess the incidence of SARS-CoV-2 transmission via corneal transplant.

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