Doncel-Fernández CJ, Alferez-Asenjo ML, Quereda-Castañeda A, et al. - This prospective study was undertaken to determine if elevated central macular thickness before uncomplicated cataract surgery can be a risk factor for developing cystic macular edema (CMEs) as measured by Cirrus-optical coherence tomography (OCT) and defined as the presence of macular intraretinal cysts. This investigation was carried out in Hospital Universitario Poniente, Almeria, Spain. Three hundred seventy-nine patients were involved for OCT before cataract surgery, the following day, at 1 month and at 3 months and the presence of macular intraretinal cysts evaluated by OCT. Excluded were patients with known risk factors for developing CME and patients who developed major surgical complications. The study was completed by 179 patients. Patients with pre-surgical macular thickness > 260.5 μm measured by Cirrus- OCT before cataract surgery, no known risk factors for developing CME, and no significant surgical complications were 9.08 times more likely after uncomplicated cataract surgery to develop macular intraretinal cysts.