Li CX, et al. - Researchers conducted this study for the purpose of primarily assessing the outcomes of patients with perihilar cholangiocarcinoma (CC), described as malignancy that arising from the biliary tract epithelia, who had surgical resection in and then analyzing risk factors affecting curative resection, tumor recurrence and overall survival (OS). Based on clinic features, operative details, tumor recurrence and long-term survival data, they retrospectively analyzed 115 individuals with perihilar CC underwent surgical resection. Data reported that the 1-, 3-, and 5-year OS rates after resection were 75.9%, 36.5%, 21.7%, while the corresponding tumor recurrence rates were 29.6%, 70.8%, 85.3%, respectively. In patients with perihilar CC, complete surgical resection, including hepatic resection, can lead to long-term survival Findings revealed that pathological factors like advanced TNM stage, lymph node and perineural invasion were independent predictors of OS and tumor recurrence. Preoperative bilirubin levels can effectively represent perihilar CC severity and as independent prognostic factors for OS and tumor recurrence after resection for perihilar CC patients.