Yang LT, Enriquez-Sarano M, Michelena HI, et al. - Researchers defined the determinants, rate, as well as outcomes of progression of aortic regurgitation (AR) in consecutive patients having ≤ moderate chronic AR quantified by effective regurgitant orifice area (EROA) and regurgitant volume (RVol) and ≥1 subsequent echocardiogram with quantitation. The study sample comprised 1,077 patients (66 ± 15 years of age), of those, 196 (18%), 465 (43%), and 416 (39%) had baseline trivial/mild AR, mild-to-moderate AR, and moderate AR, respectively. In this patient population, 21% of overall patients exhibited progression from stage B to stage C/D AR. They concluded that repeat echocardiography for trivial/mild AR at every 5 years, for mild-to-moderate AR at every 3 years, and for moderate AR at every 1 year was reasonable. In order to estimate progression rates and to recognize patients at high risk of progression, which was related to adverse outcomes, routine measurement of EROA, RVol, annulus, and sinotubular junction was recommended.