Gioli-Pereira L, Marcondes-Braga FG, Bernardez-Pereira S, et al. - Researchers used the GENIUS-HF (Genetic and ElectroNic medIcal records to predict oUtcomeS in Heart Failure patients) cohort to assess the factors that could predict 1-year survival of people with systolic heart failure. From a tertiary health-center in Sao Paulo, Brazil, the SPA outpatient clinic of the Heart Institute, 700 consecutive patients with systolic heart failure were enrolled. Cases with age between 18 and 80 years old and with heart failure diagnosis of various etiologies and left ventricular ejection fraction ≤ 50% in the past 2 years of enrollment on the cohort were considered eligible for inclusion in the study. Findings revealed that one-year overall mortality was independently predicted by high levels of blood urea nitrogen and brain natriuretic peptide and low systolic blood pressure in this study sample. Worse survival free of death and hospitalization in ischemic patients vs other etiologies was revealed in Kaplan Meier curves.