Walton E, et al. - Researchers conducted this retrospective cohort study to assess predictors of lymph node metastases (LNM) in individuals with lip cancer in order to potentially refine the selection of people for pathologic staging evaluation of the neck. Clinically N0 patients with lip squamous cell carcinoma who had definitive surgical resection and pathologic assessment of lymph node metastases in the National Cancer Data Base from 2006 to 2013. Data reported that the overall LNM rate among 786 patients was 12.1%. A prediction model was created based on proportional odd ratios from multivariant binomial logistic-regression analysis from statistically significant factors; including T2–4, moderate/poorly differentiated, or mucosal site. The prediction model found that the best candidates for elective pathologic nodal assessment were patients with two or more risk factors.