Tekin S, et al. - The predictive factors of fatality related to influenza A infection were assessed among hospitalized patients in Istanbul during the 2015-2016 influenza season, as well as the differences between infections caused by H3N2 and H1N1 in this multicenter study performed by the Istanbul Respiratory Infections Study Group of The Turkish Society of Clinical Microbiology and Infectious Diseases (KLİMİK). Out of a total of 222 patients, death was reported in 25 (11.2%) of them. They noted a significantly higher case fatality rate of influenza A(H3N2) than that of influenza A(H1N1). Multivariate analysis for the prediction of fatality revealed increased likelihood of fatality in correlation with being >65 years old, being infected with influenza A(H3N2), and a 1-day delay in antiviral use. They recommend prioritizing vaccination for at-risk groups.