Al Aseri Z, et al. - A prospective study conducted at the Department of Physiology and Department of Emergency Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia by the experts on 227 subjects to examine the correlation of high sensitivity C-reactive protein (hsCRP) estimation at first acute myocardial infarction (AMI) with myocardial dysfunction and heart failure. The levels of hsCRP levels were calculated when patients visited the emergency department at AMI, 7 days following AMI, and at 12 weeks of follow-up following AMI. Subjects were categorized into high and low C-reactive protein (CRP, have been exhibited to be associated to poor prognosis in subjects with atherothrombotic problems, heart failure, arrhythmias, and myocarditis) on the basis of cutoff mean value of hsCRP levels at admission. In comparison with the low CRP group, the ejection fraction was markedly lower at follow up in the high CRP group. The hsCRP had notable inverse association with left ventricular ejection fraction. About 38.1% subjects demonstrated heart failure, with 23.6% and 14.5% in the high CRP group and in the low CRP group, respectively. Receiver operating characteristic curve analysis presented that CRP levels at AMI had 79% and 83% of specificity and sensitivity, respectively of to prognosticate heart failure. Hence, a high hsCRP level calculated first AMI prognosticated myocardial dysfunction and heart failure. Moreover, significant role of hsCRP in the development of heart failure following myocardial infarction was suggestive.