Morales-Arraez D, et al. - Researchers sought for factors that may predict for not undergoing RNA testing among patients with positive hepatitis C virus (HCV) serology. In addition, they determined the impact of the incorporation of an automated electronic alert with recommendations in clinical practice. From October 2011 to September 2014, 41,403 HCV antibody tests were requested from 34,073 patients. Of these, 870 (2.55%) patients tested positive; RNA testing was reported in 37.6% of these following a median of follow-up of 57.0 months. Primary care serology requests, no history of drug use and a lack of social support were the independent predictors for not undergoing RNA testing. In a pre-alert cohort (October 2011-September 2014) and a post-alert cohort (October 2014-September 2015), they evaluated the impact of an automated alert notification that reminds physicians for testing RNA after a positive HCV test and referral to specialist care. Observations revealed the feasibility of implementing an automated alert for recommending RNA testing after a positive HCV antibody test in clinical practice. The incorporation of the alert led to an increase in the rate of RNA testing from 62.4% to 77.7%.