van Atteveld JE, Pluijm SMF, Ness KK, et al. - On the basis of clinical and treatment characteristics, researchers sought to develop and validate prediction models for low and very low BMD that may assist in identifying adult survivors of childhood cancer who require screening by dual-energy x-ray absorptiometry. Using dual-energy x-ray absorptiometry, lumbar spine BMD and total-body BMD were determined in white survivors of childhood cancer (n = 2,032; median attained age, 29.3 years [range, 18.1 to 40.9 years]) enrolled in the St Jude Lifetime Cohort (SJLIFE; development) and in survivors treated at the Erasmus Medical Center (validation) in the Netherlands (n = 403; median age, 24.2 years [range, 18.0 to 40.9 years]). Among SJLIFE and Dutch participants, 51% and 45%, respectively, had low BMD, and 20% and 10%, respectively, had very low BMD. The model for low BMD included male gender, height, weight, attained age, current smoking status, and cranial irradiation. Male gender, height, weight, attained age, cranial irradiation, and abdominal irradiation constituted the model for very low BMD. Validated prediction models for low and very low BMD led to accurate recognition of BMD status in most white adult survivors through age 40 years.