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Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: A meta‐analysis and systematic review

ESC Heart Failure Apr 17, 2020

Sammani A, Kayvanpour E, Bosman LP, et al. - By analyzing 55 studies with 11,451 patients (3.7 ± 2.3 years follow‐up), researchers explored the factors that predict sustained ventricular arrhythmias among patients with dilated cardiomyopathy (DCM). They identified the relevant studies by exploring MEDLINE/Embase. They applied the Quality in Prognostic Studies tool to evaluate quality and bias. Exclusion of articles with high risk of bias in ≥ 2 areas was done. The annual event rate of sustained ventricular arrhythmias was estimated to be about 4.5% in patients with DCM. A considerably higher risk was reported in relation to younger patients with hypertension, prior (non‐)sustained ventricular arrhythmia, reduced left ventricular ejection fraction, left ventricular dilatation, late gadolinium enhancement, and genetic mutations (PLNLMNA, and FLNC). Suitable candidates for implantable cardioverter‐defibrillator implantation may be selected with the help of these findings.

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