Hamada T, Yuan C, Bao Y, et al. - Researchers analyzed 423 people diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative, to prospectively assess the link between prediagnostic leukocyte telomere length and overall survival (OS) time. Additionally, they assessed 10 single nucleotide polymorphisms (SNPs) at the telomerase reverse transcriptase locus. Findings revealed an association of shorter prediagnostic leukocyte telomere length with reduced OS among patients with pancreatic cancer. Comparing the lowest to highest quintiles of leukocyte telomere length for OS, the estimated multivariable-adjusted HR was 1.39, corresponding to a 3-month difference in median OS time. In relation to the studied SNPs, there was no prognostic link or effect modification for the prognostic link of prediagnostic leukocyte telomere length.