Kedia S, et al. - Researchers examined the role of fecal calprotectin (FCP) in the diagnosis of acute severe colitis (ASC) in this prospective observational cohort study. Study participants were adult patients (> 18 years) with ulcerative colitis (UC) for whom FCP was measured and was under follow-up from April 2015 to December 2016. The findings from the present study suggested that FCP could differentiate ASC from mild to moderate patients with UC, however, requires validation before clinical use.