Postprandial endotoxemia may influence the development of type 2 diabetes mellitus: From the CORDIOPREV study
Clinical Nutrition Apr 18, 2018
Camargo A, et al. - This study examined the role of endotoxemia in promoting inflammation-induced insulin resistance (IR) in the development of type 2 diabetes mellitus (T2DM), and its usefulness as a predictive biomarker. A postprandial increase was reported in lipopolysaccharides (LPS) levels in the patients who developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months (Incident-DIAB group) at baseline. On the other hand, LPS levels were not modified in the patients who did not develop it during this period of time (Non-DIAB group). The inference drawn was that a high postprandial endotoxemia preceded the development of T2DM. The potential use of LPS plasma levels as a biomarker predictor of T2DM development was illustrated during this study.
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