Singh A, Chan PH, Prentice HA, et al. - This study was undertaken to investigate the postoperative opioid utilization as a risk factor for revision following primary shoulder arthroplasty. Researchers performed a cohort study applying data from the United States integrated healthcare system’s Shoulder Arthroplasty Registry. They distinguished individuals who had a primary elective shoulder arthroplasty (2009-2017); those with cancer or who had undergone other arthroplasty procedures (either shoulder, hip, or knee) within the preceding year were excluded. A total of 8,325 shoulder arthroplasty procedures were the final study sample. A positive association was observed between opioid consumption and aseptic revision risk following primary shoulder arthroplasty. This research cannot ascertain whether opioids have a direct physiological cause that elevates the risk of revision, rather it is likely that opioid consumption is a marker of chronic pain, poor function, and/or poor coping mechanisms. Future research is required to ascertain whether programs designed to reduce opioid use may effect revision risk after shoulder arthroplasty.