Fincham GS, et al. - The histopathologic and immunohistochemical profiles of the posterior hyaloid membrane in donated human globes with posterior vitreous detachment are compared in this study. The outcomes of this study provide immunohistochemical proof that the posterior hyaloid membrane is a true basement membrane enveloping the posterior hyaloid surface. Because this membranous structure is observed only after posterior vitreous detachment, the results of this study demonstrate that it forms part of the internal limiting membrane when the vitreous is in its attached state.