Strange G, Stewart S, Celermajer D, et al. - Focusing on the prognostic influence of all levels of native valvular aortic stenosis (AS), researchers performed this analysis on 16,129 (6.7%) patients with mild AS, 3,315 (1.4%) with moderate AS, and 6,383 (2.6%) patients with severe AS. This study did not include cases with prior aortic valve intervention. Growing risk of long-term mortality was observed in patients with mild to severe AS, on an adjusted basis. Patients with moderate AS had a 5-year mortality of 56%; this value was 67% in those with severe AS. After adjusting for age, gender, left ventricular systolic or diastolic dysfunction, and aortic regurgitation, a mean aortic valve gradient > 20.0 mm Hg (moderate AS) was found to confer a markedly raised risk of mortality from all causes (5-year mortality > 50%) and cardiovascular disease. The link of severe AS, when left untreated, with poor long-term survival was confirmed. Moreover, patients with moderate AS had poor survival rates.