Doepfner JM, et al. - Authors evaluated the impact of off-label photodynamic therapy (PDT) in combination with intravitreal off-label ziv-aflibercept or off-label aflibercept injection in patients with chronic or repeatedly recurrent acute central serous chorioretinopathy (CSC). Seemingly, combination therapy of ziv-aflibercept and aflibercept with PDT was beneficial, even in cases of chronic or repeatedly recurrent acute CSC. The CSC cases resistant to or recurrent after medical treatment, PDT alone or therapy with anti-vascular endothelial growth factor alone were included.