Sobanski V, Giovannelli J, Allanore Y, et al. - Homogeneous groups of systemic sclerosis (SSc) patients were distinguished and characterized using cluster analysis within the large European Scleroderma Trials and Research (EUSTAR) cohort, and survival was analyzed between the clusters obtained. From the EUSTAR database, the inclusion of 6,927 patients was done in the study. Based on the clinical and serologic features and disease severity and prognosis, patients were divided into 2 distinct groups on optimal clustering; researchers identified partial overlapping of these 2 categories with the classifications limited cutaneous SSc and diffuse cutaneous SSc (two subdivisions of SSc based on the extent of skin involvement). In addition, 6 homogeneous subsets of individuals were identified with an exploratory analysis that broadly differed with regard to clinical features, autoantibody profiles, and survival. Findings suggest that the complete heterogeneity of the disease could not be captured on restricting subsets of SSc patients to only those based on cutaneous involvement. Consideration of organ damage and antibody profile is recommended when individuating homogeneous groups of patients with distinct prognosis.