García-Fiñana M, et al. – In study, researchers developed a multivariate approach to accurately predict progression of sight-threatening diabetic retinopathy (STDR) in people with diabetes (PWD) within a 1-year screening interval, and evaluated the impact of simple stratification rules on prediction. They analyzed a 7-year dataset (2009-2016) from 13,103 PWD using a multivariate longitudinal discriminant approach. Findings indicated that accurate prediction of progression to STDR in PWD can be achieved utilizing a multivariate risk model while also maintaining desirable specificity. Although simple stratification rules can achieve good levels of sensitivity, the study results suggested that lower specificity (high false positive rate) may require a more prominent recurrence of eye examinations.