Seoudy H, et al. - Researchers assessed the link between periprocedural changes of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and survival post-transcatheter aortic valve implantation in 704 patients, in whom NT-proBNP levels were measured before the procedure as well as at discharge. An NT-proBNP–based ratio (postprocedural NT-proBNP at discharge/preprocedural NT-proBNP) was taken into account to classify the patients as responders and nonresponders. A significant difference was observed regarding median preprocedural (2,822 vs 1,187 pg/mL) and postprocedural (1,258 vs 3,009 pg/mL) NT-proBNP levels in responders vs nonresponders. Higher prevalence of atrial fibrillation, arterial hypertension, renal impairment, and peripheral artery disease was observed in nonresponders. Higher prevalence of moderately reduced left ventricular ejection fraction, lower calculated aortic valve area, and higher mean pressure gradient was seen among responders. The responder group vs the nonresponder group had a highly significant survival benefit. Therefore, better risk stratification was offered by a ratio based on periprocedural changes of NT-proBNP, which represents a simple tool and was related to survival in patients after transcatheter aortic valve implantation.