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Performance of vaginal self-sampling for human papillomavirus testing among women living with HIV in Botswana

International Journal of STD & AIDS Oct 16, 2019

Elliott T, et al. - Researchers performed the first assessment of self- vs provider-collected samples for high-risk human papillomavirus (hr-HPV) testing, in order to assess the feasibility of high coverage with provider-collected samples among HIV-positive women in Botswana. In addition, they reported the prevalence of hr-HPV and histological outcomes. Employing Cepheid GeneXpert, self- and provider-collected samples from HIV-positive women were tested for hr-HPV. Colposcopy was recommended for women who tested positive for any hr-HPV. Thirty-one (30%) of 103 women tested positive for any hr-HPV. HPV 31/33/35/52/58 were the most common genotypes. CIN2+ was identified in 10 of the 30 hr-HPV-positive women attending colposcopy (33%). Findings revealed an excellent agreement between self and provider samples in this HIV-positive population, and that self-sampling may play a significant role in screening programs in high HIV burden settings with limited resources like Botswana.
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