Lou S, et al. - Researchers examined, from published literature, the efficiency and safety of percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs). A total of 13 RCTs comprising 1,624 patients were involved. For the 3 primary outcomes in the subgroup of the Vertebroplasty for Acute Painful Osteoporotic fractURes (VAPOUR) trial, statistical variations were observed between PVP and the sham injection group for the blinded studies. However, pain scores were comparable between the PVP group and the sham injection group for the VAPOUR trial at each period, the impact size of PVP progressed over time. At all time points, PVP significantly decreased pain for the open-label studies. Among the PVP groups and control groups, the risk of new vertebral fractures was comparable. Therefore, only in patients with acute OVCFs having constant and severe pain, the application of PVP was efficient and safe. Moreover, among patients with older fractures or those bearing non-severe symptoms, no advantages were noted.