Holm NR, Mäkikallio T, Lindsay MM, et al. - The NOBLE trial was designed to investigate whether the percutaneous coronary intervention (PCI) was non-inferior to coronary artery bypass grafting (CABG) in the treatment of left main coronary artery disease and reported outcomes after a median follow-up of 3·1 years. A total of 1,201 patients were enrolled between Dec 9, 2008, and Jan 21, 2015. In this study, individuals were assigned randomly to PCI (n=598) or CABG (n=603), with 17 subsequently lost to early follow-up. They recruited 592 individuals in each group in this analysis. Compared with CABG, PCI was associated with an inferior clinical outcome at 5 years in revascularization of left main coronary artery disease. There was similar mortality after the two procedures but individuals treated with PCI had higher rates of non-procedural myocardial infarction and repeat revascularisation.