Yaghi S, Raz E, Dehkharghani S, et al. - In this post hoc analysis of the DEFUSE 3 trial (The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke), researchers sought to assess penumbra consumption rates for time-to-maximum (T _max) delays in patients with large vessel occlusion assessed between 6 and 16 hours from last known normal. The sample consisted of patients with an acute ischemic stroke due to anterior circulation occlusion within 6 to 16 hours of last known normal. One hundred forty-one patients were included in the study, with 68 remaining untreated. T _max >10-s mismatch volume may contain large volumes of salvageable tissue in extended window endovascular thrombectomy patients, whereas nearly half the T _max >6-s mismatch volume may remain viable in untreated patients at 24 hours.