Aka KG, Traoré DF, Sagna AB, et al. - Researchers sought to determine and compare the humoral responses specific to merozoite stage vaccine candidates of Plasmodium falciparum, in children differentially exposed to Anopheles bites in a natural setting in this cross-sectional study conducted in Bouaké (Côte d’Ivoire). They collected entomological data and blood samples from children (0–14 years) in two sites with alike malaria prevalence. Evaluation of antibody (IgG, IgG1, IgG3) responses to the P. falciparum blood-stage antigens (Ags), namely apical membrane antigen 1 (PfAMA1) and merozoite surface protein 1 (PfMSP1), was done via ELISA. Outcomes revealed differences in the anti-Plasmodium humoral responses according to the level of exposure of children; those highly exposed to Anopheles presented significantly lower antibody responses to PfMSP1 in total population (IgG and IgG3) and in Petessou village (IgG, IgG1, IgG3). They identified no significant difference for PfAMA1 antigen between children differently exposed to Anopheles. In Dar-es-Salam, a neighborhood where a high Culex density was reported, very low antibody levels specific to both antigens were identified in children, and there was no difference according to the exposure to Anopheles bites. Findings thereby suggest that immunomodulatory components of Anopheles saliva, in addition to other factors, may modulate the humoral response specific to Plasmodium merozoite stage antigens.