Fukase A, Fukui T, Sasamori H, et al. - Researchers conducted this cross-sectional study to clarify the clinical effect of pancreatic fat volume on beta cell function in T2D individuals. Participants in the study were 132 consecutive type 2 diabetic patients (mean age, 63.7 years). Using SYNAPSE VINCENT image analysis system, total pancreatic volume (TPV), pancreatic fat volume (PFV), and pancreatic parenchymal volume (PPV), and visceral fat volume were examined quantitatively with multi-detector computed tomography. Body weight (BW) was significantly associated with TPV, PFV, PPV, and visceral fat volume. PPV/BW significantly reduced with increasing duration of diabetes and aging, but not PFV/BW. PFV/BW was positively linked to BMI and visceral fat volume/BW. In patients with T2D, PFV could anticipate the progression of beta-cell dysfunction.