Bao C, et al. - Researchers investigated the link between overweight in midlife (body mass index [BMI] ≥25) and late-life cancer risk. Further, they assessed the role of genetic and early-life environmental factors in this link. From the Swedish Twin Registry, they identified that 3,968 (26.9%) were overweight and 4,253 (28.8%) had cancer among 14,766 individuals whose midlife (30–50 years) height and weight were recorded. In multi-adjusted generalized estimating equation (GEE) models, a higher risk of colon cancer, liver cancer, cervix uteri cancer, and corpus uteri cancer was related to being overweight, but a reduced risk of nonmelanoma skin cancer when normal-weight (BMI 18.5–24.9) participants were used as the reference group.