Yin J, et al. - In patients with gastric cancer, researchers examined the expression and prognostic value of serum response factor (SRF). In 149 gastric cancer samples, SRF expression was detected by immunohistochemistry. They analyzed the association between SRF expression and clinicopathological characteristics along with the prognostic significance of SRF in disease-free survival and overall survival of patients. Investigators observed that in gastric cancer tissues, SRF expression was significantly increased compared to adjacent noncancerous tissues. SRF overexpression was significantly correlated with histological differentiation, invasion depth, metastasis of the lymph node and TNM stage. In addition, the disease-free survival rate and overall survival rate for patients with high SRF expression were both significantly lower. They suggested that SRF overexpression could play an important role in the recurrence and prognosis of gastric cancer in humans. Overall, they concluded that SRF could be used as a predictive marker for gastric cancer prognosis.