Holliday EB, et al. - Researchers evaluated the survival outcomes and prognostic factors for patients with localized rectal adenocarcinoma in the National Cancer Database (NCDB) undergoing definitive radiation without surgical intervention. As per data, survival rates with a non-surgical approach to non-metastatic rectal adenocarcinoma in an unselected group of patients treated at NCDB-participating institutions were much lower than those reported in well-selected single-institutional studies. Findings suggested a correlation of moderate dose escalation from 50.4–54 Gy with better OS vs doses <50.4 Gy or >54 Gy, after adjusting for significant covariant.