Mohammad M, Andrews RM, Hay G, et al. - In this retrospective case series, researchers reported the outcomes of intravitreal methotrexate (MTX) injections to rescue eyes with relapsed primary intraocular lymphoma (PIOL). The sample consisted of patients with ocular relapse of PIOL who had initially received systemic chemotherapy (all five cases) and external beam radiotherapy (EBRT) to brain and orbits (two cases). There were nine eyes of five patients (three men; average age at first presentation 62 years) treated with the rescue protocol of intravitreal MTX injections from April 2008 to February 2016. After systemic chemotherapy and radiotherapy, intravitreal MTX was a safe and effective treatment modality for relapsed PIOL, achieving local tumour control in 89%, and is, therefore, an ideal alternative. Given the rare nature of PIOL, however, to corroborate this, larger collaborative studies with longer follow-up are required.