Sirigaddi K, et al. - Via a 16-year retrospective study, researchers assessed bacteremia outcomes for febrile sickle cell patients and analyzed risk variables including fever (either ≥ 39.5°C or ≥ 40°C), abnormal white blood cell (WBC) (>30,000 or <5,000/mcL), tachycardia, hypotension, or “ill appearing.” Analyzing 14-day readmission rates, they assessed outcomes for febrile sickle cell patients discharged from the emergency department (ED) or discharged within 72 hours. In this study, admission criteria developed using WBC count, hypotension, and “ill appearance” showed the highest sensitivity and specificity for identifying bacteremia. Discharge at 48 hours can be considered for persistently febrile, well-appearing patient, with minimal risk for new complications.