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Outcomes of diuretics in rheumatic heart disease with compensated chronic heart failure: A retrospective study

ESC Heart Failure Sep 23, 2020

Liu C, Lai Y, Guan T, et al. - Via performing this retrospective propensity score‐matched study, researchers investigated the superiority of different application approaches [continuous diuretics use (CDU) vs intermittent diuretics use (IDU)] and types [loop diuretics (LDs) vs thiazide diuretics (TDs)] of diuretics on long‐term outcomes for rheumatic heart disease (RHD) patients with compensated chronic heart failure (CHF). They analyzed a total of 494 RHD patients with compensated CHF after propensity score matching. On comparing IDU and CDU strategies for RHD patients with compensated CHF, they identified CDU to be linked with raised risks of all‐cause mortality and CVD except cerebrovascular death. Further, there was correlation of CDU with raised risks of 3‐year and 5‐year HF re‐hospitalization risk and new‐onset AF except 1‐year HF re‐hospitalization risk. On comparing TDs with LDs among study participants receiving IDU strategy, they identified link of LDs only with reduced 1‐year HF re‐hospitalization risk rather than with all‐cause mortality, CVD, cerebrovascular death, 3‐ and 5‐year HF re‐hospitalization, and new‐onset AF. In the comparison between TDs and LDs among study participants receiving CDU strategy, they identified no link of LDs with cerebrovascular death and 1‐year HF re‐hospitalization but with raised risks of all‐cause mortality, CVD, 3‐year and 5‐year HF re‐hospitalization, and new‐onset AF. Per findings, risks of all‐cause mortality, CVD, medium‐term/long‐term HF re‐hospitalization, and new‐onset AF were higher in RHD patients with compensated CHF in correlation with receiving continuous diuretics (especially LDs).

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