Maes F, et al. - In this multicenter registry (which is a substudy of the True or Pseudo-Severe Aortic Stenosis–TAVI registry) researchers assessed the clinical outcomes and changes in left ventricular ejection fraction (LVEF) after transcatheter aortic valve replacement (TAVR) in patients with low-flow, low-gradient aortic stenosis (LFLG AS) and severe left ventricular dysfunction. Overall 293 patients were included, including 128 (43.7%) with very low LVEF and 165 with low LVEF (56.3%), with a mean (SD) age of 80 (7) years, and most of whom (214 [73.0%]) were men. The mean (SD) LVEF in the very low LVEF group was 22% (5%), compared with 37% (7%) in the low LVEF group (P < .001). According to findings, greater improvements in LVEF were seen after TAVR in patients with very severe left ventricular dysfunction, these patients had similar clinical outcomes as patients with mild left ventricular dysfunction. Findings supported TAVR for LFLG AS, regardless of the severity of left ventricular dysfunction and dobutamine stress echocardiography (DSE) results.