Ahamed ZR, Dutta U, Sharma V, et al. - Since vitamin D has anti-inflammatory properties and may be beneficial in ulcerative colitis (UC), researchers analyzed the impact of oral nano vitamin D₃ supplementation on disease activity in active UC [ulcerative colitis disease activity index (UCDAI) ≥ 3]. They randomized patients with active UC and vitamin D < 40 ng/mL to receive either oral nano vitamin D (60,000 IU/d×8 d) or placebo. The authors discovered that the median vitamin D levels rose from 15.4 to 40.83 mg/dL in the vitamin D group and marginally from 13.45 to 18.85 mg/dL in controls. Compared with the control, the 3-point decrease in UCDAI was noticed more frequently in the vitamin D group. Increase in levels of vitamin D associated with a decrease in UCDAI score, C-reactive protein, and calprotectin. According to findings, oral nano vitamin D supplementation in active UC is linked to a decrease in disease activity and grade of severity and is observed more commonly in those who have attained a 40 ng/mL target vitamin D level.