Harris BR, et al. - In order to expand the reach of substance use early intervention services within and across sexual health clinics citywide and decrease substance use, poor mental health, and risky sexual behavior, Project Renew implemented Screening, Brief Intervention, and Referral to Treatment (SBIRT), an evidence-based substance use early intervention model, in eight New York City (NYC) sexual health clinics from February 2012–January 2015. Patients reported reduced alcohol and drug use six months after intervention. They also reported fewer days of depression and anxiety and less sexual activity in addition to an improvement in overall wellbeing. Additional services provided in sexual health clinics increased access to services.