Farinha C, Santos T, Santos AR, et al. - In this investigation involving 18 patients (22 eyes), researchers tested optical coherence tomography leakage in the identification and quantification of choroidal neovascularization–related fluid, its change after anti–vascular endothelial growth factor therapy in neovascular age-related macular degeneration eyes and its association with functional outcome. Individuals involved were being treated and followed according to the standard practice for nAMD with 2.0-mg intravitreal aflibercept injections in a pro re nata regimen. According to findings, optical coherence tomography leakage detected and quantified the fluid related to choroidal neovascularization activity. Low optical reflectivity change in the outer segment layer correlates with functional outcome, and an increase in LOR in the outer layers can be an early recurrence marker. The combination of optical coherence tomography angiography and optical coherence tomography leakage enables choroidal neovascularization morphology as well as activity analysis.