Estawro RG, et al. - Researchers herein detailed three cases in which optical coherence tomography angiography (OCTA) could resolve the difficulty encountered in the follow-up of proliferative macular telangiectasia type 2 (MacTel 2) cases after anti-vascular endothelial growth factor (VEGF) treatment due to staining in fluorescein angiography (FA) and alteration in retinal layers by optical coherence tomography (OCT). Diagnosis of MacTel 2 was made based on clinical examination, FA, OCT, and OCTA at presentation in this retrospective, observational case series. Using OCT and OCTA, monitoring of regression of neovessels was done. Findings support the potential value of OCTA as the tool of choice to monitor neovascular response to anti-VEGF treatment in proliferative MacTel 2.