Lima LH, Melo GB, Zett C, et al. - In the present study, the researchers reported a unique case series of diffuse unilateral subacute neuroretinitis (DUSN) patients imaged with optical coherence tomography angiography (OCTA). Multimodal imaging was performed in four patients with DUSN at the time of patient visit in this retrospective case series. Cross-sectional OCT exhibited disruption of outer retinal layers in the foveal area and an irregular structure of the outer plexiform layer. En face OCT showed hyperreflective spots and a large hyperreflective lesion in the foveal area correspondent to the outer retina disruption seen on cross-sectional OCT. OCTA displayed reduced vascular perfusion in both the superficial and deep retinal capillary plexuses along with choriocapillaris preservation. Findings suggested that OCTA may provide a more thorough evaluation of the retinal microvascular changes, allowing a more accurate anatomical-functional correlation in DUSN.