Huang SH, Tsai MS, Lee CY, et al. - Researchers examined the prevalence of Entamoeba histolytica infection (EHI), its temporal trends, and associated factors among newly diagnosed people living with HIV (PLWH) in Taiwan. They identified records of 5,362 patients who sought HIV care at six medical centers in Taiwan, during the 10-year study period. Among these patients, 119 (2.2%) had invasive amoebiasis at the time or within 6 months of their HIV diagnosis. Increase in the prevalence of invasive amoebiasis was observed from 1.3% in 2012 to 3.3% in 2018. Greater age, men who have sex with men, rapid plasma reagin titre ≥ 1:4, and concurrent shigellosis and giardiasis were noted to have independent association with invasive amoebiasis. Increasing prevalence of invasive amoebiasis among newly diagnosed PLWH in Taiwan emphasizes the necessity for strategies to prevent ongoing transmission in this population. They recommend undertaking routine screening of EHI for early diagnosis and treatment, especially among men who have sex with men and those who present with other sexually or enterically transmitted infections.