Kaplan SA, Pichardo M, Rijo E, et al. - This study was undertaken to explore one-year outcomes after treatment with a drug-coated balloon catheter system for lower urinary tract symptoms related to benign prostatic hyperplasia. Researchers included men > 50 years old with moderate-to-severe lower urinary tract symptoms (LUTS) secondary to BPH, peak urinary flow rate of 5–15 ml/s, prostatic urethra length 30–55 mm, and prostate volume 20–80 g. With the Optilume BPH Catheter System, all were treated and followed at Foley removal, 2 weeks, 30 days, 3, 6, and 12 months after treatment. The primary outcome included the proportion of individuals with ≥ 40% improvement in the International Prostate Symptom Score (IPSS). They further assessed the rate of post-procedural complications. They treated 80 individuals at six sites in Latin America and 75 completed the 1-year follow-up. Treatment with the minimally invasive Optilume BPH Catheter System was found to be safe and exhibited subjective and objective improvements in LUTS. They found rapid benefits and persisted through 1 year. The initial outcomes need the future evaluation of this therapy as a treatment option for patients with LUTS related to BPH.