Finneran MM, et al. - Women at high-risk of preeclampsia are administered low-dose aspirin for its prevention and the pathogenesis of preeclampsia involves an imbalance in prostacyclin and thromboxane A₂ (TXA₂). In addition, the nonobstetric literature suggests the possibility of more common aspirin resistance among patients with a high body mass index. Researchers examined how obesity influence platelet-derived thromboxane inhibition via performing a secondary analysis of a prospective multi-centered study investigating the effect of low-dose aspirin (60-mg) administration in women at high risk for preeclampsia. The analysis included a total of 1002 patients, 496 (49.5%) and 506 (50.5%) in the low-dose aspirin and placebo groups, respectively. Findings revealed lower rates of complete inhibition of TXB₂ among high-risk obese women receiving low-dose aspirin for the prevention of preeclampsia. Data thereby emphasize a possible requirement for increasing aspirin dose or frequency in this population.