Number of adenomas removed and colorectal cancers prevented in randomized trials of flexible sigmoidoscopy screening
Gastroenterology Jun 26, 2018
Pinsky PF, et al. - Researchers proposed 2 new metrics for quantifying the association between adenoma removal and colorectal cancer (CRC) prevented: number of adenomas needed to remove (NNR) and adenoma dwell time avoided (DTA). Data was gathered from 4 randomized trials of sigmoidoscopy screening (in the United States and 3 in Europe) for CRC to develop metrics endoscopic efficiency, NNR and DTA, that were directly associated with adenoma detection and removal. Findings suggested that it can be used to compare screening among endoscopic modalities as well as to more accurately measure adenoma to carcinoma transition rates.
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