Wladis EJ, et al. - Researchers performed immunohistochemical staining for the activated, phosphorylated variant of nuclear factor kappa-B (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12) to determine the role of nuclear factor kappa-B (NFKB) in these eyelid specimens. Outcomes showed a significantly high level of activated form of NFKB in rosacea. This suggests a role for this pathway in the pathogenesis of this disease. With the availability of clinical agents, interference with NFKB signaling may be a novel therapy for rosacea.