Razavi AC, Bazzano LA, He J, et al. - Given the value of diastolic dysfunction as one important causal factor for heart failure with preserved ejection fraction, researchers here sought for the metabolic signature associated with this subclinical phenotype. Using ultra-high-performance liquid chromatography–tandem mass spectroscopy, untargeted metabolomic analysis of fasting serum samples in 1,050 white and black participants of the BHS (Bogalusa Heart Study) was conducted. Outcomes revealed a robust association of eight metabolites with left ventricular diastolic function in the overall population; consistent associations were noted in white and black study participants. The natural log of the ratio of peak early filling velocity to mitral annular velocity was noted to be significantly correlated with the following: N-formylmethionine; 1-methylhistidine; formiminoglutamate; N2, N5-diacetylornithine; N-trimethyl 5-aminovalerate; 5-methylthioadenosine; and methionine sulfoxide. A significant association of butyrylcarnitine with isovolumic relaxation time was observed. These findings suggest the possible implications of serum metabolome, and its underlying biological pathways, in heart failure with preserved ejection fraction pathogenesis.