Mele D, Pestelli G, Dini FL, et al. - Researchers investigated whether a combined noninvasive assessment of LV forward flow, filling pressure, and right ventricular (RV) function would be better, compared with left ventricular ejection fraction (LVEF), in predicting all-cause mortality of hospitalized patients with heart failure (HF). For this purpose, they evaluated transthoracic echocardiographic assessments of a total of 603 patients hospitalized with HF. Four hemodynamic profiles were ascertained: normal flow-normal pressure, normal flow-high pressure, low flow without RV dysfunction, and low flow with RV dysfunction profile, by integrating LV stroke volume index, LV filling pressure estimation, tricuspid annular plane systolic excursion, and systolic pulmonary artery pressure in a subsample of 200 patients with HF. Experts, thereafter, employed this model in a validation cohort (n = 403). According to the findings, classification of patients hospitalized with HF as well as the prediction of all-cause mortality, independently of LVEF, was enabled by echocardiographic-derived profiling of LV forward flow, filling pressure, and RV function. This model, based on conventional echocardiography, is easy to use, and is, thus, recommended for clinical practice.