Zaid S, Sengupta A, Okoli K, et al. - Researchers inquired about the factors predictive of novel persistent left bundle branch block(NP-LBBB) following TAVI with EvolutR/PRO(ER/EP). Excluding cases with prior LBBB and pacemaker, a total of 544 patients from 2 centers who underwent TAVI with Evolut (54%ER, 46%EP) for severe native aortic stenosis between 1/2016 to 4/2019 were included in this study. NP-LBBB was identified in 76(19.2%) patients at discharge. The link of NP-LBBB in Evolut with implant depth at left coronary cusp and 34mm ER was revealed. For the prediction of NP-LBBB, optimal threshold values were membranous septal length (MSL) ≤ 6.5mm, non-coronary cusp depth ≥ 3mm and left ventricular outflow tract (LVOT) eccentricity ≥ 35%, as revealed in ROC curve analysis. New predictors of NP-LBBB in Evolut TAVI were shorter MSL, LVOT eccentricity, annular oversizing and deeper implant depth. Cases carrying risk for NP-LBBB may be recognized by preprocedural CT evaluation of aortic root anatomy. In such patients, the risk of NP-LBBB may be decreased by altering procedural factors such as higher implant and less annular oversizing.