Zhou X, Liao X, Wang X, et al. - Researchers investigated the prognostic value of phospholipase C delta (PLCD) genes in early-stage pancreatic ductal adenocarcinoma (PDAC) using the Kaplan-Meier method and multivariate Cox proportional hazards regression model. Further, they determined its potential molecular mechanisms. They performed genome-wide correlation analysis on PLCD3 to recognize the highly correlated genes in the transcriptome. In PDAC patients, certain groups of people with a history of alcoholism exhibit overexpression of PLCD3. Patients with early-stage PDAC had lower overall survival in correlation to having high expression of PLCD3. The outcome of patients with early-stage PDAC could be better predicted using a combination of PLCD3 and clinical variables comprising histological grade, targeted molecular therapy, radiation therapy, and residual resection. As per the bioinformatics analysis, there is an association of PLCD3 with angiogenesis, intracellular signal transduction, and regulation of cell proliferation. these findings support the possible prognostic role of PLCD3 as a prognostic biomarker for early-stage PDAC.