Noninvasive detection of high-risk adenomas using stool-derived eukaryotic RNA sequences as biomarkers
Gastroenterology Aug 01, 2019
Barnell E, et al. - In this investigation, researchers outlined a method for reliably extracting and evaluating stool-derived eukaryotic RNA transcripts for algorithm development that can noninvasively, sensitively, and specifically detect HRAs in a screening population. Before preparing for and undergoing colorectal cancer (CRC) screening through colonoscopy, stool samples were prospectively obtained from patients. According to findings, HRAs are essential to identify and remove owing to an annual HRA to CRC transition rate of 2.6%–5.6%, which means that the cumulative risk of cancer transformation before the next screening suggestion is roughly 12%, given a screening period of 3 years and roughly 40%, given a screening interval of 10 years.
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