Nocturnal mean arterial pressure rising is associated with mortality in the intensive care unit: A retrospective cohort study
Journal of the American Heart Association Oct 05, 2019
Li J, Li R, Gao Y, et al. - Researchers examined how nocturnal mean arterial pressure rising (NMAPR) is associated with short- and long-term mortality in critically ill adult patients. From the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) database, they included 5,185 adult patients with a complete record of mean arterial pressure monitoring during the first 24 hours of ICU stay in this retrospective cohort study. According to the value of mean nighttime divided by daytime mean arterial pressure, division of all patients into the non-NMAPR group (≤ 1; n = 1,865) or the NMAPR group (> 1; n = 3,320) was done. The analysis revealed a significant association of NMAPR with mortality in the ICU (odds ratio: 1.34), in the hospital (odds ratio: 1.35), at 28 days (hazard ratio: 1.27), and at 1 year (hazard ratio: 1.24) after adjusting for covariates. All the results of the interaction analysis were not statistically significant, and in the patients with different SOFA scores, the persistence of similar results was observed. Findings thereby suggest the possible value of NMAPR in the early recognition of critically ill patients at high risk of ICU, hospital, 28-day, or 1-year mortality.
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